Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 36, Issue -, Pages 142-148Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2016.01.007
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Funding
- NIH [R01-HG004361, P50-HG007735]
- California Institute for Regenerative Medicine
- Damon Runyon-Sohn Foundation Pediatric Cancer [DRSG-14-15]
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Structures of RNA molecules are essential for their architectural, regulatory, and catalytic functions. Recent advances in high throughput sequencing enabled the development of methods for, probing RNA structures on a transcriptome-wide scale termed the RNA structurome. Here we review the state-of-the-art technologies for probing the RNA structurome, and highlight insights gained from these studies. We also point out the limits of current methods and discuss potential directions for future improvements.
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