Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 39, Issue -, Pages 134-143Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2016.07.003
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Funding
- NSF grant [CHE-1332907]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1332907] Funding Source: National Science Foundation
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In nature, protein molecules have evolved as building blocks for the assembly of diverse and complex structures, many of which exhibit a high degree of symmetry. This observation has motivated a number of recent engineering efforts in which the advantages of symmetry have been exploited to design novel self-assembling protein structures of great size. Materials ranging from cages to extended two and three-dimensional arrays have been demonstrated. Especially for extended arrays, a vast number of geometrically different design types are possible. A table of geometric rules is provided for designing a universe of novel materials by combining two component symmetries.
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