Journal
FRONTIERS IN IMMUNOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.565683
Keywords
oral neutrophils; salivary neutrophils; head-and-neck cancer; oral squamous cell carcinoma; salivary diagnostics; oral cancer
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Funding
- Deutsche Forschungsgemeinschaft [DFG/JA 2461/2-1, DFG/JA 2461/5-1]
- Deutsche Krebshilfe [70113112]
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The composition of the oral milieu reflects oral health. Saliva provides an environment for multiple microorganisms, and contains soluble factors and immune cells. Neutrophils, which rapidly react on the changes in the microenvironment, are a major immune cell population in saliva and thus may serve as a biomarker for oral pathologies. This review focuses on salivary neutrophils in the oral cavity, their phenotype changes in physiological and pathological conditions, as well as on factors regulating oral neutrophil amount, activation and functionality, with special emphasis on oral cancer and its risk factors.
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