Epigenetic regulation of post-embryonic development

Modifications to DNA and core histones influence chromatin organization and expression of the genome. DNA methylation plays a significant role in the regulation of multiple biological processes that regulate behavior and caste differentiation in social insects. Histone modifications play significant roles in the regulation of development and reproduction in other insects. Genes coding for acetyltransferases, deacetylases, methyltransferases, and demethylases that modify core histones have been identified in genomes of multiple insects. Studies on the function and mechanisms of action of some of these enzymes uncovered their contribution to post-embryonic development. The results from studies on epigenetic modifiers could help in the identification of inhibitors of epigenetic modifiers that could be developed to control pests and disease vectors.

Automated summary

Modifications to DNA and core histones play crucial roles in chromatin organization and gene expression, affecting various biological processes. Studies have identified genes encoding enzymes that modify core histones in multiple insect genomes, with some enzymes contributing to post-embryonic development. Research on epigenetic modifiers could help identify inhibitors that may be used to control pests and disease vectors.