Journal
ANNUAL REVIEW OF VIROLOGY, VOL 7, 2020
Volume 7, Issue -, Pages 333-350Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-021820-102458
Keywords
single-cell; heterogeneity; HIV; permissiveness; latency; innate immunity; immunity
Categories
Funding
- Swiss National Science Foundation [SNF 314730-188877]
Ask authors/readers for more resources
While analyses of cell populations provide averaged information about viral infections, single-cell analyses offer individual consideration, thereby revealing a broad spectrum of diversity as well as identifying extreme phenotypes that can be exploited to further understand the complex virus-host interplay. Single-cell technologies applied in the context of human immunodeficiency virus (HIV) infection proved to be valuable tools to help uncover specific biomarkers as well as novel candidate players in virus-host interactions. This review aims at providing an updated overview of single-cell analyses in the field of HIV and acquired knowledge on HIV infection, latency, and host response. Although HIV is a pioneering example, similar singlecell approaches have proven to be valuable for elucidating the behavior and virus-host interplay in a range of other viruses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available