Journal
ADVANCED SCIENCE
Volume 7, Issue 23, Pages -Publisher
WILEY
DOI: 10.1002/advs.202000272
Keywords
layered double hydroxide; synergistic therapy; topotactic transformation; transition metal dichalcogenides
Categories
Funding
- National Natural Science Foundation of China [NSFC: 21971007, 21671013, 21601010, 21521005]
- Fundamental Research Funds for the Central Universities [buctylkxj01, XK1802-6, XK1803-05]
Ask authors/readers for more resources
Transition metal dichalcogenides (TMDs) have received considerable attention due to their strong absorption in the near-infrared (NIR) region, strong spin-orbit coupling, and excellent photothermal conversion efficiency (PCE). Herein, CoFeMn dichalcogenide nanosheets (CFMS NSs) are prepared via facile vulcanization of a lamellar CoFeMn-layered double hydroxide (LDH) precursor followed by polyvinyl pyrrolidone modification (to give CFMS-PVP NSs), and found to show excellent photoacoustic (PA) imaging and synergistic photothermal/chemodynamic therapy (PTT/CDT) performance. The as-prepared CFMS-PVP NSs inherit the ultrathin morphology of the CoFeMn-LDH precursor and exhibit an outstanding photothermal performance with a eta of 89.0%, the highest PCE reported to date for 2D TMD materials. Moreover, 50% of maximum catalytic activity (Michaelis-Menten constant,K-m) is attained by CFMS-PVP NSs with 0.26 x 10(-3)mH(2)O(2)at 318 K, markedly lower than the endogenous concentration of H(2)O(2)inside tumor cells. In addition, complete apoptosis of HepG2 cancer cells and complete tumor elimination in vivo are observed after treatment with CFMS-PVP NSs at a low dose, substantiating the NSs' remarkable PTT/CDT efficacy. This work provides a new and facile approach for the synthesis of high-quality multicomponent TMD nanosheets with precise process control, the potential for mass production, and outstanding performance, providing great promise in cancer theranostics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available