Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 6, Issue 10, Pages 5563-5570Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.0c01248
Keywords
MRSA; Gram-specific; antimicrobials; imidazolium tetramers
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Funding
- Institute of Bioengineering and Nanotechnology, Biomedical Research Council, Agency for Science, Technology and Research
- National Natural Science Foundation of China (NSFC) [81501831]
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Antimicrobial resistance poses an increasingly serious global health threat. Hence, new antimicrobials with low propensity toward inducing resistance in bacteria are being developed to combat this threat. In this work, a series of imidazolium tetramers have been synthesized by modulating the linkers between imidazoliums or the length of the end groups within the structures of oligomers in order to optimize the activity, selectivity, and biocompatibility of the compounds. These new materials possess high biocompatibility, Gram selectivity, and high efficacy against the selected bacterium as well as clinically isolated methicillin-resistant Staphylococcus aureus species without inducing drug resistance. Therefore, we believe that these compounds can potentially be used to mitigate resistance as highly effective disinfectants in healthcare products or as antimicrobial therapies specifically for Gram-positive bacterial infections.
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