Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 26, Issue -, Pages 10-15Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2015.09.007
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Funding
- People Program (Marie Curie Actions) of the European Union'sSeventh Framework Program under REA [317445]
- [Sonderforschungsbereiche SFB704]
- [SFB645]
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Macrophages are key players of tissue homeostasis and are cells involved in all major human diseases including infections, tumors, western life-style associated diseases and even neurodegenerative diseases. Therefore, specifically targeting macrophages seems to be an attractive therapeutic approach, yet such strategies have not been successfully translated to the clinic. An important hallmark of macrophages is their astounding plasticity and their capacity to integrate microenvironmental signals to perform distinct biological functions. Understanding the cellular programming of macrophages during such events will be a fundamental prerequisite to develop targeted therapeutic approaches in human diseases. Here, I highlight recent findings of how macrophage activation is regulated and how one can envision much more specific approaches of targeting macrophages.
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