Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 29, Issue -, Pages 47-53Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2016.06.003
Keywords
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Categories
Funding
- Ramon y Cajal award
- FERO VIII Fellowship
- European Research Council [336343]
- ISCIII [PI12/01604]
- MINECO [SAF2015-66312, SAF2014-54541-R]
- Health Basque Government [2015111149]
- ATRES-MEDIA-AXA
- Asociacion Espanola Contra el Cancer
- NIH [RO1 CA169416]
- DOD
- Ramon Areces Foundation
- Basque Department of Industry, Tourism and Trade (Etortek)
- Basque Department of health [2012111086]
- Basque Department of education [PI2012-03]
- Marie Curie [277043]
- Movember GAP1 project, ISCIII [PI10/01484, PI13/00031]
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Normal and tumor cells shed vesicles to the environment. Within the large family of extracellular vesicles, exosomes and microvesicles have attracted much attention in the recent years. Their interest ranges from mediators of cancer progression, inflammation, immune regulation and metastatic niche regulation, to non-invasive biomarkers of disease. In this respect, the procedures to purify and analyze extracellular vesicles have quickly evolved and represent a source of variability for data integration in the field. In this review, we provide an updated view of the potential of exosomes and microvesicles as biomarkers and the available technologies for their isolation.
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