Journal
GENES
Volume 11, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/genes11091045
Keywords
mTOR; mTORC2 signaling; Akt; signaling crosstalk
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Funding
- Marie Sklodowska-Curie Individual Fellowship [797491]
- Louis-Jeantet Foundation
- Swiss National Science Foundation
- European Research Council
- Canton of Basel
- Marie Curie Actions (MSCA) [797491] Funding Source: Marie Curie Actions (MSCA)
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Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity.
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