Journal
GENES
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/genes11101201
Keywords
hypertrophic cardiomyopathy; alpha kinase 3; ALPK3
Categories
Funding
- Russian Scientific Foundation [20-15-00271]
- Stiftelsen Frimurare Barnhuset
- Sanofi Genzyme
- Stockholm County Council [ALF 20170831]
- Russian Science Foundation [20-15-00271] Funding Source: Russian Science Foundation
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Hypertrophic cardiomyopathy associated with damaging variants in the ALPK3 gene is a fairly recent discovery, and only a small number of patients have been described thus far. Here we present two additional patients with hypertrophic cardiomyopathy caused by biallelic variants in ALPK3. Genetic investigation was performed using a targeted gene panel consisting of known cardiomyopathy-associated genes and whole exome sequencing. The patients showed a large difference in the age of onset, and both presented with extracardiac features that are often seen in ALPK3 patients. The patient with the later onset showed milder extracardiac symptoms, such as decreased muscle tone and distal muscular dystrophy, but had fast progression of cardiac complications leading to the need of heart transplantation. This study further elucidates the variability of both symptoms and age of onset among these patients.
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