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Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
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Sequence conservation between porcine and human LRRK2
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MOLECULAR BIOLOGY REPORTS (2009)
LRRK2 regulates synaptic vesicle endocytosis
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EXPERIMENTAL CELL RESEARCH (2008)
Ancient origin of the Parkinson disease gene LRRK2
Ignacio Marin
JOURNAL OF MOLECULAR EVOLUTION (2008)
Paralemmin-1, a modulator of filopodia induction is required for spine maturation
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MOLECULAR BIOLOGY OF THE CELL (2008)
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
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NATURE MEDICINE (2008)
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
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NATURE MEDICINE (2008)
Impaired learning and memory in Pitx3 deficient aphakia mice:: A genetic model for striatum-dependent cognitive symptoms in Parkinson's disease
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NEUROBIOLOGY OF DISEASE (2008)
From synapse to nucleus: Calcium-dependent gene transcription in the control of synapse development and function
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NEURON (2008)
A Drosophila model for LRRK2-linked parkinsonism
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
RAB-10 regulates glutamate receptor recycling in a cholesterol-dependent endocytosis pathway
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MOLECULAR BIOLOGY OF THE CELL (2007)
Leucine-rich repeat kinase 2 associates with lipid rafts
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HUMAN MOLECULAR GENETICS (2007)
Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain
Shinji Higashi et al.
JOURNAL OF NEUROCHEMISTRY (2007)
The familial parkinsonism gene LRRK2 regulates neurite process morphology
David MacLeod et al.
NEURON (2006)
Localization of LRRK2 to membranous and vesicular structures in mammalian brain
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ANNALS OF NEUROLOGY (2006)
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NEUROLOGY (2006)
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EMBO JOURNAL (2006)
Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms
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EMBO JOURNAL (2006)
Vesicle pools and synapsins: New insights into old enigmas
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BRAIN CELL BIOLOGY (2006)
LRRK2 expression linked to dopamine-innervated areas
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ANNALS OF NEUROLOGY (2006)
LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain
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EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease
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NEUROBIOLOGY OF DISEASE (2006)
Anatomical localization of Leucine-rich repeat kinase 2 in mouse brain
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NEUROSCIENCE (2006)
Behavioral models of Parkinson's disease in rodents: A new look at an old problem
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MOVEMENT DISORDERS (2006)
Epidemiology of Parkinson's disease
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LANCET NEUROLOGY (2006)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Building excitatory and inhibitory synapses: Balancing neuroligin partnerships
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NEURON (2005)
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NEURON (2005)
3,4-Dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice:: Behavioral characterization of a novel genetic model of Parkinson's disease
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JOURNAL OF NEUROSCIENCE (2005)
The ultrastructural distribution of alpha-synuclein-like protein in normal mouse brain
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BRAIN RESEARCH (2004)
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LANCET (2004)
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SCIENCE (2004)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
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NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
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NEURON (2004)
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CELL AND TISSUE RESEARCH (2004)
α-synuclein locus triplication causes Parkinson's disease
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SCIENCE (2003)
Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice
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MOLECULAR BRAIN RESEARCH (2003)
Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons
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DEVELOPMENT (2003)
Formation of dendritic spines in cultured striatal neurons depends on excitatory afferent activity
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EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
Pitx3 is required for development of substantia nigra dopaminergic neurons
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
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SCIENCE (2002)
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Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson's disease: clinical and therapeutic implications
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BRAIN (2000)
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