Journal
CURRENT CARDIOLOGY REPORTS
Volume 22, Issue 12, Pages -Publisher
SPRINGER
DOI: 10.1007/s11886-020-01422-x
Keywords
Obesity; Genomics; Metabolomics; Cardiometabolic; Polygenic risk score; Branched-chain amino acids
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Funding
- National Heart, Lung and Blood Institute [1R38HL143612]
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Purpose of ReviewObesity is a significant international public health epidemic with major downstream consequences on morbidity and mortality. While lifestyle factors contribute, there is an evolving understanding of genomic and metabolomic pathways involved with obesity and its relationship with cardiometabolic risk. This review will provide an overview of some of these important findings from both a biologic and clinical perspective.Recent FindingsRecent studies have identified polygenic risk scores and metabolomic biomarkers of obesity and related outcomes, which have also highlighted biological pathways, such as the branched-chain amino acid (BCAA) pathway that is dysregulated in this disease. These biomarkers may help in personalizing obesity interventions and for mitigation of future cardiometabolic risk.SummaryA multifaceted approach is necessary to impact the growing epidemic of obesity and related diseases. This will likely include incorporating precision medicine approaches with genomic and metabolomic biomarkers to personalize interventions and improve risk prediction.
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