Journal
CANCER MEDICINE
Volume 9, Issue 24, Pages 9471-9484Publisher
WILEY
DOI: 10.1002/cam4.3523
Keywords
breast cancer; gene expression omnibus; nomogram; prognostic signature
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Breast cancer (BRCA) is the most common cancer among women and is the second leading cause of cancer death in women. In this study, we developed a 9-gene prognostic signature to predict the prognosis of patients with BRCA. , , , and were used as training sets. The Kaplan-Meier plot was constructed to assess survival differences and log-rank test was performed to evaluate the statistical significance. The overall survival (OS) of patients in the low-risk group was significantly higher than that in the high-risk group. ROC analysis indicated that this 9-gene signature shows good diagnostic efficiency both in OS and disease-free survival (DFS). The 9-gene signature was further validated through , , and TCGA-BRCA datasets. We also established a nomogram that integrates clinicopathological features and 9-gene signature. The analysis of the calibration plot showed that the nomogram has good prognostic performance. More convincingly, real-time reverse transcription-polymerase chain reaction (RT-PCR) results indicated that the protective prognostic factors in BRCA patients were downregulated, whereas the dangerous prognostic factors were upregulated. The innovation of this article is not only constructing a prognostic gene signature, but also combining with clinical information to further establish a nomogram to better predict the survival probability of patients. It is worth mentioning that this signature also does not depend on other clinical factors or variables.
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