Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 39, Issue -, Pages 62-68Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2016.04.006
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Funding
- National Institutes of Health [RO1 NS050674, T32 AG000222]
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Neurons are highly polarized cells with axonal and dendritic projections that extend over long distances. Target-derived neurotrophins provide local axonal cues that function in developing neurons, while physical or chemical injuries to long axons initiate local environmental cues in mature neurons. In both instances initial responses at the location of stimulation or injury must be coordinated with changes in the transcriptional program and subsequent changes in axonal protein content. To achieve this coordination, intracellular signals move 'there and back again' between axons and the nucleus. Here, we review new findings on neuronal responses to growth factors and injury and highlight the coordination of transcription, translation and transport required to mediate communication between axons and cell bodies.
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