Journal
STEM CELLS INTERNATIONAL
Volume 2020, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2020/8860185
Keywords
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Categories
Funding
- National Science Foundation of China [81260385, 81360383]
- Clinical Research Project of Shenzhen Municipal Health Commission [SZLY2017017]
- Doctoral Project of Shenzhen Maternal and Child Health Hospital [FYA2018005]
- Medical Science and Technology Research Fund Project of Guangdong [A2019363]
- Shenzhen Science and Technology Innovation Commission [ZDSYS20190902092903237, KQJSCX20170728150303243, JCYJ20180305124812444, JCYJ20170817093928508]
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Ovarian cancer is a highly deadly disease, which is often diagnosed at a late stage with metastases. However, most ovarian cancers relapse after surgery combined with platinum-based chemotherapy. Cancer stem cells (CSCs) are stem-like cells that possess high tumorigenic capability and display higher resistant capability against current therapies. However, our knowledge of ovarian CSCs and their molecular mechanism remains sparse. In the current study, we found that KDM4C, a histone demethylase, was required for ovarian cancer stem cell (CSC) maintenance. Depletion of KDM4C significantly reduced the CSC population and sphere formation in vitro. Moreover, we found that KDM4C can regulate the expression of stem cell factor OCT-4 via binding to its promoter. These data indicate that KDM4C is relevant for ovarian CSC maintenance and underscore its importance as a potential therapeutic target.
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