Larvicidal activity of novel anthraquinone analogues and their molecular docking studies

To investigate the larvicidal activities of novel anthraquinones (1a-1k) against Culex quinquefasciatus mosquito larvae. Novel anthraquinones (1a-1k) derivatives were synthesis via condensation method. The compounds were confirmed through FT-IR spectroscopy, H-1 & C-13 NMR spectrum, and mass spectral studies. The larvicidal activity of compound 1c was highly active LD50 20.92 mu g/mL against Culex quinquefasciatus compared standard permethrin with LD50 25.49 mu g/mL. Molecular docking studies were carried out for compound 1c against Odorant-binding protein of Culex quinquefasciatus. The compound 1c (-9.8 Kcal/mol) was a potent larvicide with more binding energy than control permethrin (-9.7 Kcal/mol). Therefore, compound (1c) may be more significant inhibitors of mosquito larvicidal. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

Automated summary

By synthesizing novel anthraquinone derivatives, compound 1c was found to exhibit highly active larvicidal activity against Culex quinquefasciatus mosquito larvae, with stronger binding energy than the control permethrin. This suggests that compound 1c may be a more potent inhibitor for mosquito larvae.