Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 29, Issue -, Pages 74-80Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2015.11.002
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Funding
- Canadian Institutes of Health Research [MOP-133406]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2014-03641]
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Many bacterial pathogens use dedicated translocation systems to deliver arsenals of effector proteins to their hosts. Once inside the host cytosol, these effectors modulate eukaryotic cell biology to acquire nutrients, block microbial degradation, subvert host defenses, and enable pathogen transmission to other hosts. Among all bacterial pathogens studied to date, the gram-negative pathogen, Legionella pneumophila, maintains the largest arsenal of effectors, with over 330 effector proteins translocated by the Dot/lcm type IVB translocation system. In this review, I will discuss some of the recent work on understanding the consequences of this large arsenal. I will also present several models that seek to explain how L. pneumophila has acquired and subsequently maintained so many more effectors than its peers.
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