Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 33, Issue -, Pages 35-40Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2016.05.016
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Funding
- Canadian Institutes for Health Research (CIHR) [MOP-123477]
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R33AI098701]
- Alexander von Humboldt Foundation
- CIHR [GSD-146221]
- Canada Research Chair
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Microorganisms growing in a biofilm state are very resilient in the face of treatment by many antimicrobial agents. Biofilm infections are a significant problem in chronic and long-term infections, including those colonizing medical devices and implants. Antibiofilm peptides represent a very promising approach to treat biofilm-related infections and have an extraordinary ability to interfere with various stages of the biofilm growth mode. Antibiofilm peptides possess promising broad-spectrum activity in killing both Gram-positive and Gram-negative bacteria in biofilms, show strong synergy with conventional antibiotics, and act by targeting a universal stringent stress response. Understanding downstream processes at the molecular level will help to develop and design peptides with increased activity. Anti-biofilm peptides represent a novel, exciting approach to treating recalcitrant bacterial infections.
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