Journal
INFECTIOUS AGENTS AND CANCER
Volume 15, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13027-020-00319-2
Keywords
Prostate cancer; Microbiota; Microbiome; Gut microbiome; And urinary microbiome
Categories
Funding
- African Development bank training grant under the Uganda Cancer Institute
- Office Of The Director, National Institutes Of Health (O.D.) [D43TW010132]
- National Institute Of Dental & Craniofacial Research (NIDCR) [D43TW010132]
- National Institute Of Neurological Disorders And Stroke (NINDS) [D43TW010132]
- National Heart, Lung, And Blood Institute (NHLBI) [D43TW010132]
- Fogarty International Center (FIC) [D43TW010132]
- National Institute On Minority Health And Health Disparities (NIMHD) [D43TW010132]
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There is growing evidence of the microbiome's role in human health and disease since the human microbiome project. The microbiome plays a vital role in influencing cancer risk and pathogenesis. Several studies indicate microbial pathogens to account for over 15-20% of all cancers. Furthermore, the interaction of the microbiota, especially the gut microbiota in influencing response to chemotherapy, immunotherapy, and radiotherapy remains an area of active research. Certain microbial species have been linked to the improved clinical outcome when on different cancer therapies. The recent discovery of the urinary microbiome has enabled the study to understand its connection to genitourinary malignancies, especially prostate cancer. Prostate cancer is the second most common cancer in males worldwide. Therefore research into understanding the factors and mechanisms associated with prostate cancer etiology, pathogenesis, and disease progression is of utmost importance. In this review, we explore the current literature concerning the link between the gut and urinary microbiome and prostate cancer risk and pathogenesis.
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