Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 42, Issue -, Pages 91-97Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2016.06.008
Keywords
-
Categories
Funding
- National Institutes of Health grants [AI42767, AI85515, AI95178, AI100527]
Ask authors/readers for more resources
T cells play a major role in control of both blood and liver stage of plasmodium infection. While immunization with certain attenuated whole-parasite vaccines that are attenuated at the liver stage of the infection induces protective T cell responses, even multiple exposures to natural infection in endemic areas do not lead to stable T cell memory or humoral immunity and sterilizing protection. One of the key differences between vaccination and natural exposure is the absence of blood stage during vaccination. Here we will discuss possible immunoregulatory strategies employed by blood stage of malaria leading to generation of severely compromised T cell and humoral immune responses and subsequent lack of sterilizing immunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available