Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 38, Issue -, Pages 45-51Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2015.11.003
Keywords
-
Categories
Funding
- Canadian Institutes of Health Research (CIHR)
- Canadian Cancer Society Research Institute (CCSRI)
- Fonds de la recherche du Quebec-Sante (FRQS)
- Bristol Myers-Squibb
Ask authors/readers for more resources
The signaling lymphocytic activation molecule (SLAM) family is a group of six receptors restricted to hematopoietic cells. Most of these receptors are self-ligands, and thus are triggered in the context of interactions between hematopoietic cells. By way of their cytoplasmic domain, SLAM-related receptors associate with the SLAM-associated protein (SAP) family of adaptors, which control the signals and functions of SLAM family receptors. Recent findings have provided new insights into the key roles of SLAM family receptors in normal immunity, their involvement in human diseases and their usefulness as drug targets to treat human malignancies. These data are reviewed herein.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available