Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 39, Issue -, Pages 114-120Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2016.01.006
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Funding
- Intramural Research Program of the National Institutes of Health, the National Cancer Institute
- Center for Cancer Research
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Innate lymphoid cells (ILC) area specialized family of effector lymphocytes that transcriptionally and functionally mirror effector subsets of T cells, but differ from T cells in that they lack clonally distributed adaptive antigen receptors. Our understanding of this family of lymphocytes is still in its infancy. In this review, we summarize current understanding and discuss recent insights into the cellular and molecular events that occur during early ILC development in adult mice. We discuss how these events overlap and diverge with the early development of adaptive T cells, and how they may influence the molecular and functional properties of mature ILC.
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