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Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection

Journal

FRONTIERS IN MICROBIOLOGY
Volume 11, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.01992

Keywords

virus infection; mitochondrial fission and fusion; apoptosis; mitophagy; RIG-I-like receptors pathway

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Funding

  1. China National Key R&D Program during the 13th Five-year Plan Period [2018YFD0500802]
  2. Sichuan province's 13th Five-Year Plan breeding research project [2016NYZ0052]
  3. Sichuan veterinary medicine innovation team of National Agricultural Industry Technology System (CARSSVDIP)
  4. National Natural Science Fund [31972678, 31772773]
  5. China Scholarship Council [201906915019]

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Mitochondria are highly dynamic organelles that maintain the dynamic balance of split-fusionviakinetic proteins. This maintains the stability of their morphological functions. This dynamic balance is highly susceptible to various stress environments, including viral infection. After viral infection, the dynamic balance of the host cell mitochondria is disturbed, affecting the processes of energy generation, metabolism, and innate immunity. This creates an intracellular environment that is conducive to viral proliferation and begins the process of its own infection and causes further damage to the body. Herein, we discuss the mechanism of the virus-induced mitochondrial dynamics imbalance and its subsequent effects on the body, which will help to improve our understanding of the relationship between mitochondrial dynamics and viral infection and its importance.

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