Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 39, Issue -, Pages 136-142Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2016.01.012
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Funding
- Japan Society for the Promotion of Science [15H02506, 24390066, 15K18998]
- grant AMED-CREST from Japan Agency for Medical Research and Development
- Grants-in-Aid for Scientific Research [24390066, 15H02506, 15K18998] Funding Source: KAKEN
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The transcription repressor Bach2 is required for class switch recombination and somatic hypermutation of antibody genes in B cells, and proper development of effector and regulatory T cells. In addition, Bach2 and its related factor Bach1 promote B cell commitment of progenitor cells by repressing myeloid related genes. Bach2 and the myeloid regulators C/EBP beta and C/EBP alpha mutually repress their expression, forming a gene regulatory network (GRN) that dictates the process of lineage commitment. Bach2 forms another GRN with the plasma cell regulator Blimp-1, in which Bach2 and Blimp-1 mutually repress their expression. Since Bach2 expression is reduced in plasma cells, the repression of myeloid-related genes in B cells may be dissolved upon terminal differentiation of B cells to plasma cells. The Bach2 GRNs support the myeloid-based model of hematopoiesis. Myeloid-like characteristics suppressed or manifested in B cells by modifying differentiation trajectories of B and myeloid cells may be termed as 'inner myeloid' after the concept of 'inner fish'.
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