Journal
ELIFE
Volume 9, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.60675
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Funding
- UK Government Department of Health and Social Care
- National Institute of Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance [HPRU-2012-10041]
- Robertson Foundation
- NIHR Oxford BRC
- Wellcome Trust
- Medical Research Council [MR/N00065X/1]
- Wellcome Trust Intermediate Fellowship [110110/Z/15/Z]
- NIHR
- Medical Research Foundation [MRF-145-004-TPG-AVISO]
- Wellcome Trust [216417/Z/19/Z, 214560/Z/18/Z]
- Structural Genomics Consortium
- Kennedy Trust for Rheumatology Research
- Schmidt Foundation
- Wellcome Trust [214560/Z/18/Z] Funding Source: Wellcome Trust
- Wellcome Trust [214560/Z/18/Z] Funding Source: researchfish
- MRC [MR/N00065X/1, MC_UU_00008/6] Funding Source: UKRI
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We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15]).
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