Journal
CURRENT OPINION IN HEMATOLOGY
Volume 23, Issue 3, Pages 181-188Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOH.0000000000000231
Keywords
dyserythropoiesis; growth differentiation factor 11; hepcidin; heat shock protein 70; thalassemia
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Funding
- Agence Nationale de la Recherche
- program 'Investments for the Future' of the French National Research Agency [ANR-11-IDEX-0005-02]
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Purpose of review The review provides an overview of recent data regarding the molecular players in beta-thalassemia dyserythropoiesis and the corresponding therapeutic implications. Recent findings beta-thalassemia dyserythropoiesis is characterized by four steps: expansion of erythroid progenitors, accelerated erythroid differentiation until the polychromatophilic stage, maturation arrest, and apoptosis at the polychromatophilic stage. Excess alpha-globin chains are the primary culprit in the disease, but the link between this excess and ineffective erythropoiesis has only recently been established. Important recent advances in understanding the molecular determinants involved in two critical steps of dyserythropoiesis are paving the way to new alternative targets for the treatment of this disease. Summary Growth differentiation factor 11 (GDF11) blockade increases the apoptosis of erythroblasts with excess alpha-chains by upregulating Fas-ligand in late basophilic and polychromatophilic erythroblasts, thereby decreasing cell expansion (step 1). Blocking GDF11 alleviates anemia in a mouse model of beta-thalassemia and also in humans, most likely by promoting cells of 'good' erythroblastic lineage containing an alpha-/non-alpha-globin chain ratio of close to 1. Maturation arrest at the polychromatophilic stage (step 3) is associated with the depletion of GATA binding protein 1 (GATA-1) from the nucleus, which results from cytoplasmic sequestration of heat shock protein 70 (HSP70) by alpha-globin chains. Small molecules disrupting the HSP70/-globin complex in the cytoplasm or decreasing HSP70 nuclear export might increase the nuclear localization of HSP70, thereby protecting GATA-1 and alleviating anemia. Finally, increasing the serum levels of hepcidin or transferrin alleviates anemia and dyserythropoiesis by diminishing iron uptake by erythroblasts in mouse models.
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