Related references
Note: Only part of the references are listed.Targeting Hsp70 facilitated protein quality control for treatment of polyglutamine diseases
Amanda K. Davis et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2020)
Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones
Despina Serlidaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis
Arun Thiruvalluvan et al.
MOLECULAR CELL (2020)
Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome
Amanda B. Abildgaard et al.
BIOMOLECULES (2020)
Influence of Normal Aging on Brain Autophagy: A Complex Scenario
David A. Loeffler
FRONTIERS IN AGING NEUROSCIENCE (2019)
Spinocerebellar ataxia
Thomas Klockgether et al.
NATURE REVIEWS DISEASE PRIMERS (2019)
Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3
Sean L. Johnson et al.
NEUROBIOLOGY OF DISEASE (2019)
Chaperone-Mediated Autophagy and Its Emerging Role in Hematological Malignancies
Guillaume Robert et al.
CELLS (2019)
Toxicity and aggregation of the polyglutamine disease protein, ataxin-3 is regulated by its binding to VCP/p97 in Drosophila melanogaster
Gorica Ristic et al.
NEUROBIOLOGY OF DISEASE (2018)
Repeat-Associated Non-ATG Translation in Neurological Diseases
Tao Zu et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)
Expression and Regulation of Deubiquitinase-Resistant, Unanchored Ubiquitin Chains in Drosophila
Jessica R. Blount et al.
SCIENTIFIC REPORTS (2018)
Polyglutamine Repeats in Neurodegenerative Diseases
Andrew P. Lieberman et al.
Annual Review of Pathology-Mechanisms of Disease (2018)
Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex
Annika Scior et al.
EMBO JOURNAL (2018)
Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3
Joanna R. Sutton et al.
HUMAN MOLECULAR GENETICS (2017)
Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins
Kai Li et al.
MOLECULAR CELL (2017)
The Ubiquitination, Disaggregation and Proteasomal Degradation Machineries in Polyglutamine Disease
Samir R. Nath et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)
RNA toxicity induced by expanded CAG repeats in Huntington's disease
Eulalia Marti
BRAIN PATHOLOGY (2016)
RAN translation-What makes it run?
Katelyn M. Green et al.
BRAIN RESEARCH (2016)
Heat shock proteins as potential targets for protective strategies in neurodegeneration
Harm H. Kampinga et al.
LANCET NEUROLOGY (2016)
Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing
Elisa Giorgetti et al.
CELL REPORTS (2016)
Polyglutamine length-dependent toxicity from α1ACT in Drosophila models of spinocerebellar ataxia type 6
Wei-Ling Tsou et al.
BIOLOGY OPEN (2016)
Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms
Alyson Sujkowski et al.
AGING-US (2015)
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics
Sarah N. Fontaine et al.
HUMAN MOLECULAR GENETICS (2015)
DnaJ-1 and karyopherin α3 suppress degeneration in a new Drosophila model of Spinocerebellar Ataxia Type 6
Wei-Ling Tsou et al.
HUMAN MOLECULAR GENETICS (2015)
In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats
Grzegorz Figura et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)
The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster
Wei-Ling Tsou et al.
NEUROBIOLOGY OF DISEASE (2015)
RAN Translation in Huntington Disease
Monica Banez-Coronel et al.
NEURON (2015)
Molecular Interaction between the Chaperone Hsc70 and the N-terminal Flank of Huntingtin Exon 1 Modulates Aggregation
Elodie Monsellier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Expression of DNAJB12 or DNAJB14 Causes Coordinate Invasion of the Nucleus by Membranes Associated with a Novel Nuclear Pore Structure
Edward C. Goodwin et al.
PLOS ONE (2014)
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23
Jessica R. Blount et al.
NATURE COMMUNICATIONS (2014)
Peripheral Androgen Receptor Gene Suppression Rescues Disease in Mouse Models of Spinal and Bulbar Muscular Atrophy
Andrew P. Lieberman et al.
CELL REPORTS (2014)
HSPA8/HSC70 chaperone protein Structure, function, and chemical targeting
Francois Stricher et al.
AUTOPHAGY (2013)
Imbalance of Hsp70 family variants fosters tau accumulation
Umesh K. Jinwal et al.
FASEB JOURNAL (2013)
Ubiquitination Regulates the Neuroprotective Function of the Deubiquitinase Ataxin-3 in Vivo
Wei-Ling Tsou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model
Carlotta E. Duncan et al.
MOLECULAR NEURODEGENERATION (2013)
A Novel Mammalian ER-located J-protein, DNAJB14, Can Accelerate ERAD of Misfolded Membrane Proteins
Pattarawut Sopha et al.
CELL STRUCTURE AND FUNCTION (2012)
Expanded ATXN3 frameshifting events are toxic in Drosophila and mammalian neuron models
Shawn J. Stochmanski et al.
HUMAN MOLECULAR GENETICS (2012)
Large-Scale Screen for Modifiers of Ataxin-3-Derived Polyglutamine-Induced Toxicity in Drosophila
Hannes Vossfeldt et al.
PLOS ONE (2012)
Toward understanding Machado-Joseph disease
Maria do Carmo Costa et al.
PROGRESS IN NEUROBIOLOGY (2012)
The Josephin Domain Determines the Morphological and Mechanical Properties of Ataxin-3 Fibrils
Laura Masino et al.
BIOPHYSICAL JOURNAL (2011)
Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila
Shin-Yi Shieh et al.
HUMAN MOLECULAR GENETICS (2011)
The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRΔF508
Diane E. Grove et al.
MOLECULAR BIOLOGY OF THE CELL (2011)
Non-ATG-initiated translation directed by microsatellite expansions
Tao Zu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
A Novel ER J-protein DNAJB12 Accelerates ER-associated Degradation of Membrane Proteins Including CFTR
Yo-hei Yamamoto et al.
CELL STRUCTURE AND FUNCTION (2010)
A Genomewide RNA Interference Screen for Modifiers of Aggregates Formation by Mutant Huntingtin in Drosophila
Sheng Zhang et al.
GENETICS (2010)
Activity and Cellular Functions of the Deubiquitinating Enzyme and Polyglutamine Disease Protein Ataxin-3 Are Regulated by Ubiquitination at Lysine 117
Sokol V. Todi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target
Christopher G. Evans et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
Peter O. Bauer et al.
NATURE BIOTECHNOLOGY (2010)
Understanding the Role of the Josephin Domain in the PolyUb Binding and Cleavage Properties of Ataxin-3
Giuseppe Nicastro et al.
PLOS ONE (2010)
Splice Isoforms of the Polyglutamine Disease Protein Ataxin-3 Exhibit Similar Enzymatic yet Different Aggregation Properties
Ginny Marie Harris et al.
PLOS ONE (2010)
Josephin Domain of Ataxin-3 Contains Two Distinct Ubiquitin-Binding Sites
Giuseppe Nicastro et al.
BIOPOLYMERS (2009)
Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3
Sokol V. Todi et al.
EMBO JOURNAL (2009)
Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability
Umesh K. Jinwal et al.
JOURNAL OF NEUROSCIENCE (2009)
Ubiquitin-binding domains - from structures to functions
Ivan Dikic et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Nucleocytoplasmic Shuttling Activity of Ataxin-3
Sandra Macedo-Ribeiro et al.
PLOS ONE (2009)
Spatial and temporal control of gene expression in drosophila using the inducible GeneSwitch GAL4 system. I. Screen for larval nervous system drivers
Louise Nicholson et al.
GENETICS (2008)
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains
Brett J. Winborn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
RNA toxicity is a component of ataxin-3 degeneration in Drosophila
Ling-Bo Li et al.
NATURE (2008)
Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity
Sokol V. Todi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3:: In vivo evidence
Ulrike Bichelmeier et al.
JOURNAL OF NEUROSCIENCE (2007)
The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step
Andrew M. Ellisdon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
A Boeddrich et al.
EMBO JOURNAL (2006)
Defining the role of ubiquitin-interacting motifs in the polyglutamine disease protein, ataxin-3
SJS Berke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The solution structure of the Josephin domain of ataxin-3: Structural determinants for molecular recognition
G Nicastro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila
K Iijima-Andot et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism
JM Warrick et al.
MOLECULAR CELL (2005)
CAG repeats containing CAA interruptions form branched hairpin structures in spinocerebellar ataxia type 2 transcripts
K Sobczak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Construction of transgenic Drosophila by using the site-specific integrase from phage φC31
AC Groth et al.
GENETICS (2004)
Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases
MD Marmor et al.
ONCOGENE (2004)
Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3
L Masino et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
RNA structure of trinucleotide repeats associated with human neurological diseases
K Sobczak et al.
NUCLEIC ACIDS RESEARCH (2003)
Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila
HYE Chan et al.
HUMAN MOLECULAR GENETICS (2002)
Conditional expression of UAS-transgenes in the adult eye with a new gene-switch vector system
G Roman et al.
GENESIS (2002)
Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor
AP Lieberman et al.
HUMAN MOLECULAR GENETICS (2002)
A conditional tissue-specific transgene expression system using inducible GAL4
T Osterwalder et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Mechanisms of chaperone suppression of polyglutamine disease:: selectivity, synergy and medullation of protein solubility in Drosophila
HYE Chan et al.
HUMAN MOLECULAR GENETICS (2000)