Related references
Note: Only part of the references are listed.p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle
Hui Che et al.
ELIFE (2020)
Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro
Hosni Cherif et al.
JOURNAL OF CLINICAL MEDICINE (2019)
Emerging senolytic agents derived from natural products
Wen Li et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2019)
High mobility group box-1 induces pro-inflammatory signaling in human nucleus pulposus cells via toll-like receptor 4-dependent pathway
Bhranti S. Shah et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2019)
Systemic clearance of p16INK4a-positive senescent cells mitigates age-associated intervertebral disc degeneration
Prashanti Patil et al.
AGING CELL (2019)
What low back pain is and why we need to pay attention
Jan Hartvigsen et al.
LANCET (2018)
Senolytics improve physical function and increase lifespan in old age
Ming Xu et al.
NATURE MEDICINE (2018)
Senotherapeutics for healthy ageing
Laura J. Niedernhofer et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells
HyunTae V. Hwang et al.
PLOS ONE (2018)
Effects of senolytic drugs on human mesenchymal stromal cells
Clara Grezella et al.
STEM CELL RESEARCH & THERAPY (2018)
Fisetin is a senotherapeutic that extends health and lifespan
Matthew J. Yousefzadeh et al.
EBIOMEDICINE (2018)
THERMOREVERSIBLE HYALURONAN-HYDROGEL AND AUTOLOGOUS NUCLEUS PULPOSUS CELL DELIVERY REGENERATES HUMAN INTERVERTEBRAL DISCS IN AN EX VIVO, PHYSIOLOGICAL ORGAN CULTURE MODEL
D. H. Rosenzweig et al.
EUROPEAN CELLS & MATERIALS (2018)
Animal models for disc degeneration-an update
Li Jin et al.
HISTOLOGY AND HISTOPATHOLOGY (2018)
The Clinical Potential of Senolytic Drugs
James L. Kirkland et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2017)
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
Ok Hee Jeon et al.
NATURE MEDICINE (2017)
Senescent cells: an emerging target for diseases of ageing
Bennett G. Childs et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Senotherapy: growing old and staying young?
Roland Schmitt
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2017)
Cellular Senescence: A Translational Perspective
James L. Kirkland et al.
EBIOMEDICINE (2017)
Therapeutic interventions for aging: the case of cellular senescence
Abel Soto-Gamez et al.
DRUG DISCOVERY TODAY (2017)
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463
Yi Zhu et al.
AGING-US (2017)
Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia
Michael Andreeff et al.
CLINICAL CANCER RESEARCH (2016)
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
Yi Zhu et al.
AGING CELL (2016)
Vanillin Analogues o-Vanillin and 2,4,6-Trihydroxybenzaldehyde Inhibit NFκB Activation and Suppress Growth of A375 Human Melanoma
Annamaria Marton et al.
ANTICANCER RESEARCH (2016)
Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways
Chencheng Feng et al.
CELL CYCLE (2016)
Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research
[Anonymous]
MILITARY MEDICINE (2016)
Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration
F. Wang et al.
OSTEOARTHRITIS AND CARTILAGE (2016)
A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic
Chris Daly et al.
BIOMED RESEARCH INTERNATIONAL (2016)
DYNAMIC LOADING, MATRIX MAINTENANCE AND CELL INJECTION THERAPY OF HUMAN INTERVERTEBRAL DISCS CULTURED IN A BIOREACTOR
D. H. Rosenzweig et al.
EUROPEAN CELLS & MATERIALS (2016)
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Yi Zhu et al.
AGING CELL (2015)
Mechanics and biology in intervertebral disc degeneration: a vicious circle
P. -P. A. Vergroesen et al.
OSTEOARTHRITIS AND CARTILAGE (2015)
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Ming Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Organ Culture Bioreactors - Platforms to Study Human Intervertebral Disc Degeneration and Regenerative Therapy
Benjamin Gantenbein et al.
CURRENT STEM CELL RESEARCH & THERAPY (2015)
Why Do Some Intervertebral Discs Degenerate, When Others (in the Same Spine) Do Not?
Michael A. Adams et al.
CLINICAL ANATOMY (2015)
Axial T1ρ MRI as a diagnostic imaging modality to quantify proteoglycan concentration in degenerative disc disease
Kyle R. Mulligan et al.
EUROPEAN SPINE JOURNAL (2015)
Painful, degenerating intervertebral discs up-regulate neurite sprouting and CGRP through nociceptive factors
Emerson Krock et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2014)
Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative
Claudio B. S. Oliveira et al.
MOLECULES (2014)
The role of senescent cells in ageing
Jan M. van Deursen
NATURE (2014)
High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain
Rahul Gawri et al.
ARTHRITIS RESEARCH & THERAPY (2014)
Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration
Abbie L. A. Binch et al.
ARTHRITIS RESEARCH & THERAPY (2014)
MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models
Christian Tovar et al.
CANCER RESEARCH (2013)
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tamara Tchkonia et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Juan Carlos Acosta et al.
NATURE CELL BIOLOGY (2013)
The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc
Kate L. E. Phillips et al.
ARTHRITIS RESEARCH & THERAPY (2013)
Expression and significance of VEGF and p53 in degenerate intervertebral disc tissue
Xiao-Yu Lu et al.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE (2013)
Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development
Binh Vu et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
Theo Vos et al.
LANCET (2012)
MDM2 inhibition in liposarcoma: a step in the right direction
Anastasia Constantinidou et al.
LANCET ONCOLOGY (2012)
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
Isabelle Ray-Coquard et al.
LANCET ONCOLOGY (2012)
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle
Shauna A. Henley et al.
CELL DIVISION (2012)
Development of an Organ Culture System for Long-Term Survival of the Intact Human Intervertebral Disc
Rahul Gawri et al.
SPINE (2011)
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
Jean -Philippe Coppe et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
Patented inhibitors of p53-Mdm2 interaction (2006-2008)
Lutz Weber
EXPERT OPINION ON THERAPEUTIC PATENTS (2010)
A Role for CXCR2 in Senescence, but What about in Cancer?
Juan C. Acosta et al.
CANCER RESEARCH (2009)
Increased cell senescence is associated with decreased cell proliferation in vivo in the degenerating human annulus
Helen E. Gruber et al.
SPINE JOURNAL (2009)
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
Thomas Kuilman et al.
CELL (2008)
Chemokine signaling via the CXCR2 receptor reinforces senescence
Juan C. Acosta et al.
CELL (2008)
The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons
Jun-Gang Wang et al.
MOLECULAR PAIN (2008)
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe et al.
PLOS BIOLOGY (2008)
Are animal models useful for studying human disc disorders/degeneration?
Mauro Alini et al.
EUROPEAN SPINE JOURNAL (2008)
Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons
Hosung Jung et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Cellular senescence: when bad things happen to good cells
Judith Campisi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
Christine Lyn Le Maitre et al.
ARTHRITIS RESEARCH & THERAPY (2007)
Validity and interobserver agreement of a new radiographic grading system for intervertebral disc degeneration: Part I. Lumbar spine
Hans-Joachim Wilke et al.
EUROPEAN SPINE JOURNAL (2006)
Cellular senescence in aging primates
U Herbig et al.
SCIENCE (2006)
Possible pathogenesis of painful intervertebral disc degeneration
BG Peng et al.
SPINE (2006)
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation
S Parrinello et al.
JOURNAL OF CELL SCIENCE (2005)
Molecular mechanisms of E2F-dependent activation and pRB-mediated repression
MV Frolov et al.
JOURNAL OF CELL SCIENCE (2004)
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
LT Vassilev et al.
SCIENCE (2004)
Free radical scavenging activity of vanillin and o-vanillin using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical
SS Kumar et al.
REDOX REPORT (2002)
Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
KJ Livak et al.
METHODS (2001)
Share Paper
