4.6 Review

Neurogenesis After Stroke: A Therapeutic Perspective

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Perlecan Domain-V Enhances Neurogenic Brain Repair After Stroke in Mice

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Summary: The extracellular matrix fragment perlecan domain V has been shown to have neuroprotective and functionally restorative effects following experimental stroke, with its effects on neurogenesis being regulated by alpha 2 beta 1 integrin. This suggests that domain V could be a potential novel therapy for stroke with a broad therapeutic window.

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