Journal
TOXINS
Volume 12, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/toxins12090542
Keywords
green tea polyphenols; Sambucus ebulus; ebulin f; RIP; lectin; ribosome-inactivating protein; ricin
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Funding
- Junta de Castilla y Leon [GR106]
- Junta de Castilla y Leon (Consejeria de Sanidad)
- UVa-GIR
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The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controversy due to reported adverse effects. We underwent a preliminary exploration of the effects of the oral administration of a standardized concentrated GTPs preparation on mice which suffered from reversible intestinal derangement promoted by sublethal amounts of the antiribosomal lectin ebulin f from dwarf elder (Sambucus ebulusL.). Neither independent oral administration of 30 mg/kg body weight Polyphenon 60 nor intraperitoneal administration of 2.5 mg/kg body weight ebulin f triggered lethal toxicity. In contrast, the simultaneous administration of these same doses of both Polyphenon 60 and ebulin f triggered an important and unexpected synergistic toxic action featured by the biphasic reduction of weight, which continued after eight days, reaching a reduction of 40%. Lethality appeared 2 days after the onset of the combined treatment and reached more than 50% after 10 days.
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