Journal
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
Volume 19, Issue 1, Pages 26-30Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0000000000000242
Keywords
longevity; metabolomics; microbiota; probiotics; sarcopenia
Categories
Ask authors/readers for more resources
Purpose of reviewThis article summarizes our current knowledge of changes in the intestinal microbiota in elderly people and centenarians.Recent findingsAge-related processes comprise specific changes in the intestinal microbiota and related metabolic alterations. They result in inflamm-aging', which is associated with age-related inflammatory processes and diseases, including cachexia, frailty, cancer, and metabolic as well as neurological diseases. Age-related microbial changes consist of an increase in proteolytic bacteria and a decrease in saccharolytic bacteria. These changes are associated with sarcopenia and longevity, and might be attenuated by pre and probiotics. These findings could explain, at least in part, why probiotics have been successfully used in elderly people for the treatment of respiratory and gastrointestinal infections, and for the enhancement of vaccination responses.SummaryThe intestinal microbiota changes with age. These changes are of relevance in regard to morbidity and mortality in the elderly population. Dietetic (probiotics, prebiotics) and other lifestyle interventions might delay, or even reverse, such alterations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available