Journal
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
Volume 19, Issue 1, Pages 31-36Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0000000000000230
Keywords
bone; muscle; myostatin; osteoporosis; sarcopenia
Categories
Funding
- Servier
- Novartis
- Negma
- Lilly
- Wyeth
- Amgen
- GlaxoSmithKline
- Roche
- Merckle
- Nycomed-Takeda
- NPS
- IBSA-Genevrier
- Theramex
- UCB
- Asahi Kasei
- Endocyte
- Merck Sharp and Dohme
- Rottapharm
- Teijin
- Teva
- Analis
- NovoNordisk
- Ebewee Pharma
- Zodiac
- Will Pharma
- Meda
- Bristol Myers Squibb
- IBSA
- Merck Sharp Dohme
- Nutraveris
- Pfizer
- SMB
- Bayer
- Genevrier
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Purpose of reviewThis article reviews recently published evidence for common pathways explaining bone and muscle wasting in normal ageing and pathological conditions.Recent findingsNumerous studies support the concept of a bone-muscle unit, where constant cross-talking between the two tissues takes place, involving molecules released by the skeletal muscle secretome, which affects bone, and osteokines secreted by the osteoblasts and osteocytes, which, in turn, impact muscle cells.SummaryNew chemical entities aiming at concomitantly treating osteoporosis and sarcopenia could be developed by targeting pathways that centrally regulate bone and muscle or emerging pathways that facilitate the communication between the two tissues.
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