Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 34, Issue -, Pages 20-29Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2016.05.011
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Funding
- CAMBIOS Project of the Spanish Ministry of Economy and Competitiveness [RTC-2014-1777-3]
- EVOPROG [FP7-ICT-610730]
- ARISYS [ERC-2012-ADG-322797]
- EmPowerPutida of the European Union [EU-H2020-BIOTEC-2014-2015-6335536]
- PROMPT Project of the Autonomous Community of Madrid [CAM-S2010/BMD-2414]
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The soil bacterium Pseudomonas putida is endowed with a central carbon metabolic network capable of fulfilling high demands of reducing power. This situation arises from a unique metabolic architecture that encompasses the partial recycling of triose phosphates to hexose phosphates - the so-called EDEMP cycle. In this article, the value of P. putida as a bacterial chassis of choice for contemporary, industrially-oriented metabolic engineering is addressed. The biochemical properties that make this bacterium adequate for hosting biotransformations involving redox reactions as well as toxic compounds and intermediates are discussed. Finally, novel developments and open questions in the continuous quest for an optimal microbial cell factory are presented at the light of current and future needs in the area of biocatalysis.
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