Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 43, Issue -, Pages 7-13Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2016.06.002
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Funding
- SystemsX.ch RTD project Cell Plasticity
- Swiss Cancer League
- Swiss National Science Foundation
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An epithelial to mesenchymal transition (EMT) is a process of cell remodeling critical during embryonic development and organogenesis. During an EMT, epithelial cells lose their polarized organization and acquire migratory and invasive capabilities. While a plethora of experimental results have indicated that manipulating an EMT also affects cancer metastasis, its reverse process, a mesenchymal to epithelial transition (MET), seems to support metastatic outgrowth in distant organs. Moreover, recent reports investigating cancer cells circulating in the blood stream or employing genetic lineage-tracing have questioned a critical role of an EMT in metastasis formation. Hence, we need to better understand the molecular networks underlying the cell plasticity conferred by an EMT or a MET and its functional contribution to malignant tumor progression.
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