Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 39, Issue -, Pages 43-52Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2016.02.001
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Funding
- NCI NIH HHS [P01 CA128814, R35 CA197465, R01 CA179170] Funding Source: Medline
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Mitochondrial dynamics encompasses processes associated with mitochondrial fission and fusion, affecting their number, degree of biogenesis, and the induction of mitophagy. These activities determine the balance between mitochondrial energy production and cell death programs. Processes governing mitochondrial dynamics are tightly controlled in physiological conditions and are often deregulated in cancer. Mitochondrial protein homeostasis, transcriptional regulation, and post-translational modification are among processes that govern the control of mitochondrial dynamics. Cancer cells alter mitochondrial dynamics to resist apoptosis and adjust their bioenergetic and biosynthetic needs to support tumor initiating and transformation properties including proliferation, migration, and therapeutic resistance. This review focuses on key regulators of mitochondrial dynamics and their role in cancer.
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