Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 40, Issue -, Pages 131-136Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2016.03.017
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Funding
- Israel Science Foundation [176/11]
- Chief Scientist Office of the Israel Ministry of Health [3-00000-6014]
- Israeli Cancer Association [20141044]
- Israeli centers of research excellence (I-CORE), Gene Regulation in Complex Human Disease [41/11]
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Common fragile sites (CFSs) are chromosomal regions characterized as hotspots for breakage and chromosomal rearrangements following DNA replication stress. They are preferentially unstable in pre-cancerous lesions and during cancer development. Recently CFSs were found to be tissue-and even oncogene-induced specific, thus indicating an unforeseen complexity. Here we review recent developments in CFS research that shed new light on the molecular basis of their instability and their importance in cancer development.
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