Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 40, Issue -, Pages 131-136Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2016.03.017
Keywords
-
Categories
Funding
- Israel Science Foundation [176/11]
- Chief Scientist Office of the Israel Ministry of Health [3-00000-6014]
- Israeli Cancer Association [20141044]
- Israeli centers of research excellence (I-CORE), Gene Regulation in Complex Human Disease [41/11]
Ask authors/readers for more resources
Common fragile sites (CFSs) are chromosomal regions characterized as hotspots for breakage and chromosomal rearrangements following DNA replication stress. They are preferentially unstable in pre-cancerous lesions and during cancer development. Recently CFSs were found to be tissue-and even oncogene-induced specific, thus indicating an unforeseen complexity. Here we review recent developments in CFS research that shed new light on the molecular basis of their instability and their importance in cancer development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
