Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 40, Issue -, Pages 168-178Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2016.03.022
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Funding
- National Institutes of Health (NIH) [GM083337, GM085354]
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DNA replication is essential for faithful transmission of genetic information and is intimately tied to chromosome structure and function. Genome duplication occurs in a defined temporal order known as the replication-timing (RT) program, which is regulated during the cell cycle and development in discrete units referred to as replication domains (RDs). RDs correspond to topologically-associating domains (TADs) and are spatio-temporally compartmentalized in the nucleus. While improvements in experimental tools have begun to reveal glimpses of causality, they have also unveiled complex context-dependent relationships that challenge long recognized correlations of RT to chromatin organization and gene regulation. In particular, RDs/TADs that switch RT during development march to the beat of a different drummer.
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