Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 39, Issue -, Pages 84-92Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2016.02.008
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Funding
- NIH [5R01GM114276, 5U01CA199216, 5UL1TR00108502, TG2-01159]
- Stanford Department of Research
- Baxter Laboratory
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The primary cilium is an antenna-like cellular protrusion mediating sensory and neuroendocrine signaling. Its localization within tissue architecture and a growing list of cilia-localized receptors, in particular G-protein-coupled receptors, determine a host of crucial physiologies, which are disrupted in human ciliopathies. Here, we discuss recent advances in the identification and characterization of ciliary signaling components and pathways. Recent studies have highlighted the unique signaling environment of the primary cilium and we are just beginning to understand how this design allows for highly amplified and regulated signaling.
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