Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 41, Issue -, Pages 117-124Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2016.05.003
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Funding
- UCSF Liver Center [P30 DK026743]
- NIH [R01 AI097552]
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Hepatitis C virus (HCV) is a major cause of liver disease worldwide. To establish and maintain chronic infection, HCV extensively rearranges cellular organelles to generate distinct compartments for viral RNA replication and virion assembly. Here, we review our current knowledge of how HCV proliferates and remodels ER-derived membranes while preserving and expanding associated lipid droplets during viral infection. Unraveling the molecular mechanisms responsible for HCV-induced membrane reorganization will enhance our understanding of the HCV life-cycle, the associated liver pathology, and the biology of the ER: lipid droplet interface in general.
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