Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 42, Issue -, Pages 94-101Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2016.05.006
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Funding
- BBSRC [BB/N001133/1, BB/L007584/1, BB/J015032/1]
- Fight for Sight [1393, 1740/1741]
- Wellcome Trust [201057/Z/16/Z]
- [ST 15 07 I]
- BBSRC [BB/N014855/1, BB/J015032/1, BB/N001133/1, BB/H002294/1, BB/L007584/1] Funding Source: UKRI
- MRC [G0900098, G0400678, G0700743] Funding Source: UKRI
- Wellcome Trust [201057/Z/16/Z] Funding Source: Wellcome Trust
- Biotechnology and Biological Sciences Research Council [BB/H002294/1, BB/L007584/1, BB/J015032/1, BB/N001133/1, BB/N014855/1] Funding Source: researchfish
- British Heart Foundation [FS/16/23/32071] Funding Source: researchfish
- Fight for Sight [1846/1847, 1393/94] Funding Source: researchfish
- Medical Research Council [G0900098, G0400678, G0700743] Funding Source: researchfish
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Formation of tissue barriers by epithelial and endothelial cells requires neighbouring cells to interact via intercellular junctions, which includes tight junctions. Tight junctions form a semipermeable paracellular diffusion barrier and act as signalling hubs that guide cell behaviour and differentiation. Components of tight junctions are also expressed in cell types not forming tight junctions, such as cardiomyocytes, where they associate with facia adherens and/or gap junctions. This review will focus on tight junction proteins and their importance in tissue homeostasis and remodelling with a particular emphasis on what we have learned from animal models and human diseases.
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