Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 38, Issue -, Pages 24-30Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2016.01.004
Keywords
-
Categories
Funding
- European Research Council [281903]
- Human Frontier Science Program
- Netherlands Organization for Scientific Research (NWO, Rubicon)
- European Research Council (ERC) [281903] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Chirality or mirror asymmetry is a common theme in biology found in organismal body plans, tissue patterns and even in individual cells. In many cases the emergence of chirality is driven by actin cytoskeletal dynamics. Although it is well established that the actin cytoskeleton generates rotational forces at the molecular level, we are only beginning to understand how this can result in chiral behavior of the entire actin network in vivo. In this review, we will give an overview of actin driven chiralities across different length scales known until today. Moreover, we evaluate recent quantitative models demonstrating that chiral symmetry breaking of cells can be achieved by properly aligning molecular-scale torque generation processes in the actomyosin cytoskeleton.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available