Journal
JOURNAL OF FLOW CHEMISTRY
Volume 11, Issue 2, Pages 127-134Publisher
SPRINGER
DOI: 10.1007/s41981-020-00116-3
Keywords
Continuous-flow; Photochemistrys; Conjugated allylic bromination; Scalable productivity
Categories
Funding
- Natural Science Foundation of China [21776254]
- Natural Science Foundation of Zhejiang Province [LQ20B060006]
Ask authors/readers for more resources
A continuous-flow process for the bromination of conjugated allylic compounds with N-bromosuccinimide (NBS) was developed and optimized. The productivity under optimal conditions reached 70.5 g/h, and the conversion rate and selectivity were significantly improved compared to batch-mode synthesis. Additionally, the reaction time was reduced from hours to minutes.
A continuous-flow process for the bromination of conjugated allylic compounds with N-bromosuccinimide (NBS) is developed. The reaction was optimized in a self-made continuous-flow photoreactor based on a commercially available household lamp. The productivity of this continuous step attains 70.5 g/h under the optimal conditions. Compared to batch-mode synthesis, the conversion rate and selectivity of this flow-mode was significantly improved. In addition, the reaction time could be significantly reduced from a few hours to a few minutes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
