Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 37, Issue -, Pages 88-96Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2015.10.006
Keywords
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Funding
- USDA Cooperative State Research, Education and Extension Service (Hatch project) [ILLU-698-339]
- University of Illinois Graduate College Dissertation Completion Fellowship
- Energy Biosciences Institute
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Cell wall lytic enzymes have been of increasing interest as antimicrobials for targeting Gram-positive spoilage and pathogenic bacteria, largely due to the development of strains resistant to antibiotics and bacteriophage therapy. Such lysins show considerable promise against Listeria monocytogenes, a primary concern in food-processing environments, but there is room for improvement via protein engineering. Advances in antilisterial applications could benefit from recent developments in lysin biotechnology that have largely targeted other organisms. Herein we present various considerations for the future development of lysins, including environmental factors, cell physiology concerns, and dynamics of protein architecture. Our goal is to review key developments in lysin biotechnology to provide a contextual framework for the current models of lysin-cell interactions and highlight key considerations for the characterization and design of novel lytic enzymes.
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