Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 40, Issue -, Pages 113-118Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2016.03.011
Keywords
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Funding
- National Institute for General Medical Sciences [R01GM102428, R15GM101636]
- Marine Biological Laboratories Whitman Center fellows program
- Pew Scholars Program in the Biomedical Sciences
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Cells assemble mitotic spindles during each round of division to insure accurate segregation of their duplicated genome. In animal cells, stereotypical spindles have two poles, each containing one centrosome, from which microtubules are nucleated. By contrast, many cancer cells often contain more than two centrosomes and form transient multipolar spindle structures with more than two poles. In order to divide and produce viable progeny, the multipolar spindle intermediate must be reshaped into a pseudo-bipolar structure via a process called centrosomal clustering. Pseudo-bipolar spindles appear to function normally during mitosis, but they occasionally give rise to aneuploid and transformed daughter cells. Agents that inhibit centrosomal clustering might therefore work as a potential cancer therapy, specifically targeting mitosis in supernumerary centrosome-containing cells.
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