Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 40, Issue -, Pages 56-63Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2016.02.011
Keywords
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Funding
- NIH [NIDCR R03DE021755]
- American Heart Association Scientist Development Grant [12SDG8980014]
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Protein domains and peptide sequences are a powerful tool for conferring specific functions to engineered biomaterials. Protein sequences with a wide variety of functionalities, including structure, bioactivity, protein-protein interactions, and stimuli responsiveness, have been identified, and advances in molecular biology continue to pinpoint new sequences. Protein domains can be combined to make recombinant proteins with multiple functionalities. The high fidelity of the protein translation machinery results in exquisite control over the sequence of recombinant proteins and the resulting properties of protein-based materials. In this review, we discuss protein domains and peptide sequences in the context of functional protein-based materials, composite materials, and their biological applications.
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