Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 40, Issue -, Pages 90-96Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2016.02.015
Keywords
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Funding
- NIH [P20GM103432]
- National Science Foundation Faculty Early Career Development (CAREER) Program [BBBE 1254608]
- Department of Defense (Congressionally Directed Medical Research Program) [W81XWH-13-1-0273]
- Department of Defense (Prostate Cancer Research Program) [W81XWH-13-1-0273]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1254608] Funding Source: National Science Foundation
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The microfabrication of microfluidic control systems and the development of increasingly sensitive molecular amplification tools have enabled the miniaturization of single cells analytical platforms. Only recently has the throughput of these platforms increased to a level at which populations can be screened at the single cell level. Techniques based upon both active and passive manipulation are now capable of discriminating between single cell phenotypes for sorting, diagnostic or prognostic applications in a variety of clinical scenarios. The introduction of multiphase microfluidics enables the segmentation of single cells into biochemically discrete picoliter environments. The combination of these techniques are enabling a class of single cell analytical platforms within great potential for data driven biomedicine, genomics and transcriptomics.
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