Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 38, Issue -, Pages 54-62Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2015.12.017
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Funding
- National Science Foundation [EEC-0813570]
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Advances in metabolic engineering have allowed for the development of new biological catalysts capable of selectively de-functionalizing biomass to yield platform molecules that can be upgraded to biobased chemicals using high efficiency continuous processing allowed by heterogeneous chemical catalysis. Coupling these disciplines overcomes the difficulties of selectively activating C-OH bonds by heterogeneous chemical catalysis and producing petroleum analogues by biological catalysis. We show that carboxylic acids, pyrones, and alcohols are highly flexible platforms that can be used to produce biobased chemicals by this approach. More generally, we suggest that molecules with three distinct functionalities may represent a practical upper limit on the extent of functionality present in the platform molecules that serve as the bridge between biological and chemical catalysis.
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