Journal
HUMAN VACCINES & IMMUNOTHERAPEUTICS
Volume 16, Issue 10, Pages 2363-2365Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2020.1799669
Keywords
Cytokine storm; COVID-19; severe acute respiratory syndrome coronavirus 2; pro-inflammatory cytokines; chemokines
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The cytokine storm following sepsis has been proven to be an important mechanism for triggering acute respiratory distress syndrome, which is a fatal uncontrolled systemic inflammation characterized by high concentrations of pro-inflammatory cytokines and chemokines, secreted by immune effector cells. The cytokine storm also occurs in the recently emerged novel coronavirus disease (COVID-19). Therefore, cytokines which usually help the immune system to fight infections are potentially harmful in the course of COVID-19 infections. Therefore, avoiding or mitigating the cytokine storm may be a key treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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