Dilemma in post-IBD patients with IBS-D symptoms: A 2020 overview

Introduction Inflammatory bowel disease (IBD) patients in apparent clinical remission who present with irritable bowel syndrome (IBS)-like symptoms pose a diagnostic and therapeutic dilemma that is called post-IBD IBS. When associated with a diarrheal IBS presentation, this clinical syndrome is known as post-IBD IBS-D. Areas covered We review and describe the literature regarding the clinical overlap of IBD and IBS. We discuss prevalent theories regarding the pathophysiology of post-IBD IBS-D and whether this presentation represents coincident inherent IBS-D, IBS-D triggered by IBD, or an even more subtle level of IBD activity that is unrecognized by available laboratory modalities. We also discuss observations that post-IBD IBS-D patients harbor significantly increased colon mucosal eosinophils and appear to respond to a GI-hypoallergenic diet and budesonide therapy. Expert opinion The symptoms overlap between IBD and IBS complicates diagnosis and subsequent management of patients with post-IBD IBS-D. In addition to current theories regarding the pathophysiology of this condition such as alterations in mucosal inflammation, the microbiota, mucosal permeability, and gut-brain interactions. This new avenue of eosinophilic colopathy and therapy directed toward food-derived immune response in patients with post-IBD IBS-D deserves additional investigation.

Automated summary

The overlap of clinical symptoms between IBD and IBS complicates the diagnosis and management of post-IBD IBS-D patients. The prevalent theories regarding the pathophysiology of this condition include alterations in mucosal inflammation, the microbiota, mucosal permeability, and gut-brain interactions. Investigation into eosinophilic colopathy and therapy focused on food-derived immune response in patients with post-IBD IBS-D is warranted.